The molecular basis of Streptococcus equi infection and disease

Microbes Infect. 2002 Apr;4(4):501-10. doi: 10.1016/s1286-4579(02)01565-4.


Streptococcus equi is the aetiological agent of strangles, one of the most prevalent diseases of the horse. The animal suffering and economic burden associated with this disease necessitate effective treatment. Current antibiotic therapy is often ineffective and thus recent attention has focused on vaccine development. A systematic understanding of S. equi virulence, leading to the identification of targets to which protective immunity can be directed, is a prerequisite of the development of such a vaccine. Here, the virulence factors of S. equi are reviewed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacterial Adhesion
  • Bacterial Proteins / chemistry
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Carrier Proteins / chemistry
  • Carrier Proteins / genetics
  • Carrier Proteins / metabolism
  • Horse Diseases / microbiology*
  • Horses / microbiology*
  • Streptococcal Infections / microbiology*
  • Streptococcal Infections / veterinary
  • Streptococcal Vaccines / chemistry
  • Streptococcal Vaccines / immunology
  • Streptococcus equi / enzymology
  • Streptococcus equi / genetics
  • Streptococcus equi / pathogenicity*
  • Streptococcus equi / physiology*
  • Virulence


  • Bacterial Proteins
  • Carrier Proteins
  • Streptococcal Vaccines