Overexpression of cyclin D1 and underexpression of p27 predict lymph node metastases in papillary thyroid carcinoma

J Clin Endocrinol Metab. 2002 Apr;87(4):1814-8. doi: 10.1210/jcem.87.4.8353.


Lymph node metastasis in papillary thyroid carcinoma increases the morbidity of treatment and the risk of local regional relapse and may also affect cure rates and survival. Factors that predict lymph node metastasis are, however, unclear. We analyzed 125 patients with papillary thyroid carcinoma for factors that predict lymph node metastasis. On univariate analysis, age, extrathyroidal extension, tumor focality, overexpression of cyclin D1, and underexpression of p27 predicted lymph node metastasis, whereas patient gender and tumor size did not. On multivariate analysis, extrathyroidal extension, overexpression of cyclin D1, and underexpression of p27 proved to be strong independent predictors of lymph node metastasis. We suggest that immunohistochemistry for cyclin D1 and p27 will prove valuable in identifying papillary thyroid carcinomas with metastatic potential.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Papillary / metabolism*
  • Carcinoma, Papillary / pathology
  • Carcinoma, Papillary / secondary*
  • Cell Cycle Proteins / metabolism*
  • Cyclin D1 / metabolism*
  • Cyclin-Dependent Kinase Inhibitor p27
  • Female
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Neoplasm Invasiveness
  • Prognosis
  • Thyroid Neoplasms / metabolism*
  • Thyroid Neoplasms / pathology*
  • Tumor Suppressor Proteins / metabolism*


  • Cell Cycle Proteins
  • Tumor Suppressor Proteins
  • Cyclin D1
  • Cyclin-Dependent Kinase Inhibitor p27