Cardiorespiratory fitness and stroke mortality in men

Med Sci Sports Exerc. 2002 Apr;34(4):592-5. doi: 10.1097/00005768-200204000-00005.


Purpose: We examined the association between cardiorespiratory fitness and stroke mortality in men.

Methods: This is a prospective cohort study. We followed 16,878 men, ages 40-87 yr, who had a complete medical evaluation including a maximal treadmill exercise test and self-reported health habits. There were 32 stroke deaths during an average of 10 yr of follow-up (167,961 man-yr).

Results: After adjustment for age and examination year, there was an inverse association between cardiorespiratory fitness and stroke mortality (P = 0.005 for trend). This association remained after further adjustment for cigarette smoking, alcohol intake, body mass index, hypertension, diabetes mellitus, and parental history of coronary heart disease (P = 0.02 for trend). High-fit men (most fit 40%) had 68% (95% CI: 0.12, 0.82) and moderate-fit men had 63% (95% CI: 0.17, 0.83) lower risk of stroke mortality when compared with low-fit men (least fit 20%), respectively.

Conclusions: Moderate and high levels of cardiorespiratory fitness were associated with lower risk of stroke mortality in men in the Aerobics Center Longitudinal study population.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiovascular Physiological Phenomena*
  • Cohort Studies
  • Exercise / physiology
  • Follow-Up Studies
  • Humans
  • Life Style
  • Male
  • Middle Aged
  • Physical Fitness / physiology*
  • Prospective Studies
  • Respiratory Physiological Phenomena*
  • Risk
  • Stroke / mortality*
  • United States / epidemiology