Mining genome databases to identify and understand new gene regulatory systems

Curr Opin Microbiol. 2002 Apr;5(2):149-53. doi: 10.1016/s1369-5274(02)00309-0.


The availability of a large number of sequenced microbial genomes allows us to conduct systematic studies on microbial gene regulatory systems. Computational methods, using comparative genomics approaches, are powerful tools to understand their mechanisms and evolutionary history. Recent advances in computational methodology for uncovering transcriptional regulatory components and their interactions are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Computational Biology
  • Databases as Topic
  • Genes, Regulator*
  • Genome, Bacterial*
  • Transcription, Genetic