Cell signaling: life or death decisions of ras proteins

Curr Biol. 2002 Apr 2;12(7):R259-61. doi: 10.1016/s0960-9822(02)00787-x.

Abstract

The discovery of a new downstream target for the Ras GTPases - a Nore1-Mst1 protein complex - reveals a mechanism by which Ras can promote apoptosis, and suggests that the influence of Ras on cell survival or death depends upon the relative level of activation of its various target proteins.

Publication types

  • Comment
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing*
  • Animals
  • Apoptosis*
  • Carrier Proteins / metabolism*
  • Genes, Tumor Suppressor*
  • Humans
  • Monomeric GTP-Binding Proteins / metabolism*
  • Neoplasm Proteins / genetics
  • Neoplasm Proteins / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*
  • Tumor Suppressor Proteins*
  • ras Proteins / metabolism*

Substances

  • Adaptor Proteins, Signal Transducing
  • Carrier Proteins
  • Neoplasm Proteins
  • RASSF1 protein, human
  • RASSF5 protein, human
  • Rassf5 protein, mouse
  • Tumor Suppressor Proteins
  • Phosphatidylinositol 3-Kinases
  • STK4 protein, human
  • Stk4 protein, mouse
  • Protein-Serine-Threonine Kinases
  • Monomeric GTP-Binding Proteins
  • ras Proteins