Primary osteosarcoma of the uterine corpus: case report and review of the literature

Pathol Int. 2002 Feb;52(2):158-63. doi: 10.1046/j.1440-1827.2002.01325.x.


A rare case of rapidly growing osteosarcoma that developed in the uterine corpus of a 62-year-old woman is presented. The tumor occupied almost the entire pelvic cavity and extended into the abdominal cavity, with marked involvement of the intestines. Histopathologically, the tumor was composed of an osteoblastic component, accompanied by conspicuous bone formation, and a fibroblastic component. The tumor cells were positive for vimentin and osteocalcin, as well as desmin, alpha-smooth muscle actin and muscle-specific actin, but negative for h-caldesmon. The results indicated myofibroblastic differentiation in a part of the tumor. A review of 14 reported cases and our case of uterine osteosarcoma revealed that this tumor has a biologically aggressive nature, although its histopathological and immunohistochemical features are similar to those of osteosarcomas in soft tissue and bone. As the prognosis of patients with this tumor is poor, it is of importance to differentiate this tumor from other types of tumors arising from the uterine corpus.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Actins / analysis
  • Desmin / analysis
  • Female
  • Humans
  • Immunohistochemistry
  • Microscopy, Electron
  • Middle Aged
  • Muscle, Smooth / chemistry
  • Osteocalcin / analysis
  • Osteosarcoma / metabolism
  • Osteosarcoma / pathology*
  • Osteosarcoma / ultrastructure
  • Uterine Neoplasms / metabolism
  • Uterine Neoplasms / pathology*
  • Uterine Neoplasms / ultrastructure
  • Uterus / chemistry
  • Uterus / pathology
  • Vimentin / analysis


  • Actins
  • Desmin
  • Vimentin
  • Osteocalcin