Interleukin-2 in the pathogenesis of perinatal white matter damage

Neurology. 2002 Apr 9;58(7):1125-8. doi: 10.1212/wnl.58.7.1125.


Proinflammatory cytokines were reported to be implicated in the pathogenesis of perinatal white matter lesions. The authors document for the first time the in situ detection of interleukin-2 and interleukin-2 receptor (IL-2R) in these human white matter lesions. These results suggest that interleukin-2, reported to be toxic to oligodendrocytes and myelin, could play a role in the molecular cascade leading to white matter damage in periventricular leukomalacia.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / metabolism*
  • Brain / pathology*
  • Cytokines / analysis
  • Cytokines / biosynthesis
  • Female
  • Humans
  • Infant Mortality
  • Infant, Newborn / metabolism*
  • Infant, Premature* / metabolism
  • Interleukin-2 / analysis
  • Interleukin-2 / biosynthesis*
  • Male
  • Statistics, Nonparametric


  • Cytokines
  • Interleukin-2