Dermatitis, glossitis, stomatitis, cheilitis, anemia and weight loss: a classic presentation of pancreatic glucagonoma

W V Med J. Jan-Feb 2002;98(1):12-4.


Glucagonomas are rare tumors. They are predominantly located in the body or tail of the pancreas and display a constellation of signs and symptoms referred to as glucagonoma syndrome. The term necrolytic migratory erythema is used to characterize the distinctive rash associated with this syndrome. This report describes a classic presentation consisting of dermatitis, glossitis, stomatitis, angular cheilitis, anemia, and weight loss that was associated with the finding of a pancreatic mass and a markedly elevated plasma glucagon level. After pancreatic resection, the patient had complete resolution of the rash and normalization of plasma glucagon.

Publication types

  • Case Reports

MeSH terms

  • Anemia / etiology
  • Dermatitis / etiology
  • Female
  • Glossitis / etiology
  • Glucagonoma / complications
  • Glucagonoma / diagnosis*
  • Glucagonoma / pathology
  • Humans
  • Middle Aged
  • Pancreatic Neoplasms / complications
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / pathology
  • Stomatitis / etiology
  • Syndrome
  • Weight Loss