Clinicopathologic features and outcomes of intraductal papillary-mucinous tumors of the pancreas

Hepatogastroenterology. Jan-Feb 2002;49(43):263-7.

Abstract

Background/aims: The authors reviewed their experience with resected IPMT (intraductal papillary-mucinous tumor) of the pancreas to clarify the characteristics and prognosis of this neoplasm.

Methodology: Between 1983 and 1998, 30 consecutive patients with IPMT underwent operations at our institution. Their clinicopathological features and postoperative long-term outcomes were analyzed retrospectively.

Results: There were 22 males and 8 females, with a mean age of 64 years. Operations performed were duodenum-preserving pancreatic head resection in 12 patients, distal pancreatectomy in 8, segmental pancreatectomy in 6, conventional pancreaticoduodenectomy in 4. Malignancy was found in 10 of 30 (33%). Factors significantly associated with malignancy were tumor size or presence in main pancreatic duct. In 30 resected patients after a mean follow-up of 60 months, tumor recurrence had occurred in 2 cases of invasive carcinoma that infiltrated into the extrapancreatic organ. The overall actuarial 5-year and 10-year survival was 83% and 62%, respectively.

Conclusions: IPMT has a favorable prognosis after adequate resection. Despite slow growth, IPMT has an obvious malignant potential and a poor prognosis when invasive carcinoma has developed. Early recognition and pancreatectomy is the mainstay of treatment for IPMT.

MeSH terms

  • Adenocarcinoma, Mucinous / physiopathology*
  • Adenocarcinoma, Mucinous / surgery
  • Adenocarcinoma, Papillary / physiopathology*
  • Adenocarcinoma, Papillary / surgery
  • Adult
  • Aged
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pancreatectomy
  • Pancreatic Neoplasms / physiopathology*
  • Pancreatic Neoplasms / surgery
  • Pancreaticoduodenectomy
  • Prognosis
  • Retrospective Studies
  • Survival Analysis
  • Survivors
  • Treatment Outcome