Sequential MRI in a case of Creutzfeldt-Jakob disease

Neuroradiology. 2002 Mar;44(3):223-6. doi: 10.1007/s002340100695.


A 48-year-old man suddenly developed clinically and electroencephalographically nonspecific dementia. On MRI sequences, only diffusion-weighted images (DWI) of the cortex were unequivocally pathological. Obvious atrophy and basal ganglia signal changes appeared only 9 months after the onset. Brain biopsy confirmed Creutzfeldt-Jakob disease (CJD). In rapidly progressive dementia, we recommend DWI for early diagnosis of CJD.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain / pathology*
  • Contrast Media
  • Creutzfeldt-Jakob Syndrome / diagnosis*
  • Electroencephalography
  • Gadolinium DTPA
  • Humans
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy
  • Male
  • Middle Aged
  • Time Factors


  • Contrast Media
  • Gadolinium DTPA