Identification of Proteins Involved in Cytokinesis of Dictyostelium

Cell Struct Funct. 2001 Dec;26(6):571-5. doi: 10.1247/csf.26.571.

Abstract

Dictyostelium is one of the model systems of choice for studying the cytokinesis of animal-type cells. Two types of cytokinesis mutants have been used to identify proteins involved in the cytokinesis of Dictyostelium: (1) type I, the mutant cells grow on substrates to produce giant multinucleate cells; (2) type II, the mutant cells divide nearly normally on substrates, but are unable to divide at all and get highly multinucleate in suspension culture. These two mutant types might correspond to the myosin II-independent and myosin II-including cytokinesis mechanisms, respectively.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / genetics
  • Cell Division / physiology*
  • Dictyostelium / cytology
  • Dictyostelium / genetics
  • Dictyostelium / physiology*
  • Mutation
  • Myosin Type II / genetics
  • Myosin Type II / metabolism
  • Protozoan Proteins / genetics
  • Protozoan Proteins / metabolism*

Substances

  • Protozoan Proteins
  • Myosin Type II