Extraction studies of Tabernanthe iboga and Voacanga africana

Nat Prod Lett. 2002 Feb;16(1):71-6. doi: 10.1080/1057563029001/4881.


The root bark of Tabernanthe iboga contains ibogaine as its predominant alkaloid and has been an important source of it. Ibogaine is used experimentally to interrupt drug addiction and allow therapeutic intervention, but is currently unaffordable to doctors in less economically developed countries. To meet this need, an extraction of alkaloids from T. iboga root bark was optimized and simplified to use only diluted vinegar and ammonia, and was successfully applied to related alkaloids from Voacanga africana bark also. The alkaloids were converted to their hydrochlorides and purified, and the minor alkaloids were recovered.

MeSH terms

  • Alkaloids / chemical synthesis*
  • Alkaloids / chemistry*
  • Alkaloids / economics
  • Bridged-Ring Compounds / chemical synthesis
  • Bridged-Ring Compounds / chemistry
  • Chromatography, Thin Layer
  • Ibogaine / analogs & derivatives*
  • Ibogaine / chemical synthesis
  • Ibogaine / chemistry
  • Indole Alkaloids / chemical synthesis
  • Indole Alkaloids / chemistry
  • Molecular Structure
  • Plant Bark / chemistry
  • Plant Roots / chemistry
  • Plants, Medicinal / chemistry*
  • Substance-Related Disorders / drug therapy
  • Tabernaemontana / chemistry*


  • Alkaloids
  • Bridged-Ring Compounds
  • Indole Alkaloids
  • ibogamine
  • Ibogaine
  • ibogaline
  • voacangine