The allograft inflammatory factor-1 family of proteins

FEBS Lett. 2002 Mar 13;514(2-3):115-21. doi: 10.1016/s0014-5793(02)02430-4.


The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma-inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. Three proteins are probably identical with AIF-1 termed Iba1 (ionized Ca(2+)-binding adapter), MRF-1 (microglia response factor) and daintain. Considerable but not complete sequence identity with AIF-1 has been described for IRT-1 (interferon-responsive transcript), BART-1 (balloon angioplasty-responsive transcript), and other, yet unassigned alternatively spliced variants. In this review, genomic and functional characteristics of AIF-1-related proteins are summarized and a common nomenclature is proposed.

Publication types

  • Review

MeSH terms

  • Alternative Splicing
  • Animals
  • Calcium-Binding Proteins / chemistry
  • Calcium-Binding Proteins / genetics*
  • Calcium-Binding Proteins / metabolism
  • Conserved Sequence
  • DNA-Binding Proteins / genetics
  • Humans
  • Membrane Proteins / genetics
  • Mice
  • Microfilament Proteins
  • Molecular Sequence Data
  • Multigene Family
  • Nerve Tissue Proteins / genetics
  • Rats
  • Sequence Alignment
  • Sequence Homology, Amino Acid
  • Sequence Homology, Nucleic Acid
  • Swine


  • AIF1 protein, human
  • Aif1 protein, mouse
  • Aif1 protein, rat
  • Calcium-Binding Proteins
  • DNA-Binding Proteins
  • Membrane Proteins
  • Microfilament Proteins
  • Nerve Tissue Proteins