Antifungal drug resistance of pathogenic fungi

Lancet. 2002 Mar 30;359(9312):1135-44. doi: 10.1016/S0140-6736(02)08162-X.


Pathogenic fungi have many complex mechanisms of resistance to antifungal drugs. Information about the clinical, cellular, and molecular factors contributing to antifungal-drug resistance continues to accumulate. We critically review the diagnosis, epidemiology, and mechanisms of antifungal drug resistance of pathogenic fungi. Better understanding of this resistance should assist in developing better detection strategies for preventing and treating refractory mycoses in the future.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Antifungal Agents / therapeutic use*
  • Candida / drug effects
  • Candida / genetics
  • Candidiasis / drug therapy
  • Candidiasis / microbiology
  • Drug Resistance, Fungal* / genetics
  • Drug Resistance, Multiple, Fungal / genetics
  • Humans
  • Microbial Sensitivity Tests
  • Mycoses / drug therapy*
  • Mycoses / microbiology


  • Antifungal Agents