Sec61beta--a component of the archaeal protein secretory system

Trends Biochem Sci. 2002 Apr;27(4):170-1. doi: 10.1016/s0968-0004(01)02055-2.


Sec61p/SecYEG complexes mediate protein translocation across membranes and are present in both eukaryotes and bacteria. Whereas homologues of Sec61alpha/SecY and Sec61gamma/SecE exist in archaea, identification of the third component (Sec61beta or SecG) has remained elusive. Using PSI-BLAST, the archaeal counterpart of Sec61beta has been detected. With the identification of the Sec61beta motif, functions for a universal family of archaeal proteins can be predicted and the archaeal translocon system can be definitively detected.

MeSH terms

  • Amino Acid Motifs
  • Amino Acid Sequence
  • Archaeal Proteins / metabolism*
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Molecular Sequence Data
  • SEC Translocation Channels
  • Sequence Homology, Amino Acid


  • Archaeal Proteins
  • Membrane Proteins
  • SEC Translocation Channels

Associated data

  • GENBANK/AE000914
  • GENBANK/AE006662