Chromatin Remodeling Enzymes: Taming the Machines. Third in Review Series on Chromatin Dynamics

EMBO Rep. 2002 Apr;3(4):319-22. doi: 10.1093/embo-reports/kvf075.

Abstract

Members of the ATP-dependent family of chromatin remodeling enzymes play key roles in the regulation of transcription, development, DNA repair and cell cycle. Each of these enzymes are multi-subunit assemblies that hydrolyze thousands of molecules of ATP in order to change nucleosome positions, disrupt DNA-histone interactions and perhaps destabilize chromatin folding. Here I review recent studies that suggest these potent machines can be 'tamed' by one of several mechanisms: targeting their activity to localized regions, blocking their chromatin binding activity or inhibiting their remodeling activity.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Animals
  • Chromatin / enzymology*
  • DNA / metabolism*
  • Drosophila Proteins / genetics
  • Gene Expression Regulation
  • Histones / metabolism*
  • Humans
  • Polycomb Repressive Complex 1

Substances

  • Chromatin
  • Drosophila Proteins
  • Histones
  • Pc protein, Drosophila
  • Adenosine Triphosphate
  • DNA
  • Polycomb Repressive Complex 1