Mechanisms of cross-talk between G-protein-coupled receptors

Neurosignals. 2002 Jan-Feb;11(1):45-57. doi: 10.1159/000057321.


There is increasing evidence to suggest that 'cross-talk' occurs between G-protein-coupled receptors and their intracellular second messenger pathways. Cross-talk between different pathways may occur at the level of receptors, G-proteins, effectors or second messengers and may serve to fine-tune cell signalling. There is a growing body of evidence to suggest that cellular compartmentalization may play a crucial role in regulating these cross-talk interactions. Understanding the mechanisms of cross-talk may therefore be the key to the design and application of future therapeutics and the development of drug specificity.

Publication types

  • Review

MeSH terms

  • Animals
  • GTP-Binding Proteins / physiology*
  • Humans
  • Receptor Cross-Talk / physiology*
  • Receptors, Cell Surface / physiology*
  • Second Messenger Systems / physiology*


  • Receptors, Cell Surface
  • GTP-Binding Proteins