Networks and crosstalk: integrin signalling spreads

Nat Cell Biol. 2002 Apr;4(4):E65-8. doi: 10.1038/ncb0402-e65.


Multicellular organisms must coordinate signals from adhesion receptors with those from other signalling receptors (for example, growth factor receptors). Here, we briefly review paradigms of integrin-adhesion-receptor signalling. We discuss how adhesive signalling is coordinately regulated through intersecting networks. We also examine some examples of how some forms of integrin crosstalk may lead to unforeseen and potentially deleterious responses.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Division
  • Humans
  • Integrins / metabolism*
  • MAP Kinase Signaling System*
  • Models, Biological
  • Phosphorylation
  • Receptors, Growth Factor / metabolism
  • Signal Transduction*


  • Integrins
  • Receptors, Growth Factor