Intercellular adhesion, signalling and the cytoskeleton

Nat Cell Biol. 2002 Apr;4(4):E101-8. doi: 10.1038/ncb0402-e101.


Connections between the cytoskeleton and intercellular junctions profoundly influence cell shape and motility. It is becoming increasingly clear that in addition to structural functions, components of the adhesion apparatus also possess signalling capabilities. Recent studies suggest that their dual function may provide the means to integrate changes in morphology and gene expression during tissue and organ development.

Publication types

  • Review

MeSH terms

  • Adherens Junctions / ultrastructure
  • Cell Adhesion
  • Cytoskeleton / ultrastructure*
  • Desmosomes / ultrastructure
  • Gene Expression Regulation, Developmental
  • Keratinocytes / ultrastructure
  • Microscopy, Confocal
  • Models, Biological
  • Signal Transduction*
  • Time Factors