Polymorphism in the human C-reactive protein (CRP) gene, plasma concentrations of CRP, and the risk of future arterial thrombosis

Atherosclerosis. 2002 May;162(1):217-9. doi: 10.1016/s0021-9150(01)00703-1.


While increased concentrations of C-reactive protein (CRP) are associated with increased vascular risk, little information is available describing genetic determinants of this effect. In a large prospective cohort of apparently healthy men, we found plasma CRP concentrations to be significantly reduced among carriers of a 1059G/C polymorphism in the human CRP gene (GC or CC) as compared with non-carriers (GG). However, the polymorphism examined was not significantly associated with risk of arterial thrombosis despite the fact that CRP concentrations are a potent independent predictor of future vascular events in this cohort. These data suggest that genetic and environmental determinants each importantly contribute to the vascular risk associated with inflammation.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Alleles
  • Arteries / pathology*
  • C-Reactive Protein / genetics*
  • C-Reactive Protein / metabolism*
  • Case-Control Studies
  • Cohort Studies
  • Coronary Thrombosis / blood*
  • Coronary Thrombosis / genetics*
  • Gene Frequency / genetics
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Myocardial Infarction / blood
  • Myocardial Infarction / genetics
  • Polymorphism, Genetic / genetics
  • Predictive Value of Tests
  • Risk Factors
  • Time Factors


  • C-Reactive Protein