Serum iron, ferritin, folic acid, and vitamin B12 levels in recurrent aphthous stomatitis

J Eur Acad Dermatol Venereol. 2002 Jan;16(1):66-7. doi: 10.1046/j.1468-3083.2002.00369.x.


Background: The exact aetiology of recurrent aphthous stomatitis (RAS) is still unknown, but different predisposing factors, including iron, vitamin B12 and folic acid deficiencies, have been proposed.

Material and methods: Serum iron, ferritin, folic acid and vitamin B12 levels were investigated in 35 patients with RAS and in 26 healthy controls.

Results: Vitamin B12 levels were found significantly lower in subjects with RAS than in controls. No significant differences were found in other parameters.

Conclusion: We concluded that vitamin B 12 deficiency may be an aetiological factor in recurrent aphthous stomatitis.

MeSH terms

  • Adolescent
  • Adult
  • Chi-Square Distribution
  • Female
  • Ferritins / blood*
  • Folic Acid / blood*
  • Humans
  • Iron / blood*
  • Male
  • Middle Aged
  • Recurrence
  • Statistics, Nonparametric
  • Stomatitis, Aphthous / blood*
  • Stomatitis, Aphthous / etiology
  • Vitamin B 12 / blood*
  • Vitamin B 12 Deficiency / complications


  • Ferritins
  • Folic Acid
  • Iron
  • Vitamin B 12