Genetic risk factors of chronic obstructive pulmonary disease

Swiss Med Wkly. 2002 Jan 26;132(3-4):27-37.

Abstract

Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD). However, only a minority of cigarette smokers develop symptomatic disease. Family and twin studies suggest that genetic factors also contribute to the development of COPD. We present a detailed literature review of the genes which have been investigated as potential risk factors for this disease.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics
  • Epoxide Hydrolases / genetics
  • Genes
  • Genetic Predisposition to Disease*
  • Glutathione Transferase / genetics
  • Heme Oxygenase (Decyclizing) / genetics
  • Heme Oxygenase-1
  • Humans
  • Interleukin-1 / genetics
  • Membrane Proteins
  • Pulmonary Disease, Chronic Obstructive / genetics*
  • Receptors, Adrenergic, beta / genetics
  • Risk Factors
  • Tumor Necrosis Factor-alpha / genetics
  • Vitamin D-Binding Protein / genetics
  • alpha 1-Antitrypsin Deficiency / genetics

Substances

  • CFTR protein, human
  • Interleukin-1
  • Membrane Proteins
  • Receptors, Adrenergic, beta
  • Tumor Necrosis Factor-alpha
  • Vitamin D-Binding Protein
  • Cystic Fibrosis Transmembrane Conductance Regulator
  • HMOX1 protein, human
  • Heme Oxygenase (Decyclizing)
  • Heme Oxygenase-1
  • Glutathione Transferase
  • Epoxide Hydrolases