Patients' perceptions of the effects of systemic lupus erythematosus on health, function, income, and interpersonal relationships: a comparison with Wegener's granulomatosis

Arthritis Rheum. 2002 Apr 15;47(2):196-201. doi: 10.1002/art.10341.


Objective: To describe the patients' perceptions of the effects of systemic lupus erythematosus (SLE) and Wegener's granulomatosis (WG) on health, function, income, and interpersonal relationships.

Methods: 114 patients with SLE, and 79 patients with WG completed a self-administered questionnaire. Patients had been diagnosed with SLE or WG for a median period of 10 and 5 years, respectively.

Results: All patients experienced substantial functional morbidity. Two-thirds of the patients with SLE or WG reported either a periodic or permanent inability to perform daily activities at home and/or at work. Furthermore, SLE as well as WG had a considerable impact upon the psychological and social life, affecting their happiness and altering relationships.

Conclusion: Our study demonstrates that SLE and WG are associated with substantial medical morbidity resulting in physical and occupational disability. SLE has a profound impact on patients' lives, similar to that experienced in patients with WG.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Attitude to Health
  • Child
  • Employment
  • Female
  • Granulomatosis with Polyangiitis / physiopathology
  • Granulomatosis with Polyangiitis / psychology*
  • Humans
  • Income
  • Interpersonal Relations
  • Lupus Erythematosus, Systemic / physiopathology
  • Lupus Erythematosus, Systemic / psychology*
  • Male
  • Middle Aged
  • Patients / psychology
  • Surveys and Questionnaires