Neuroprotective effects of propofol following global cerebral ischemia in rats

Neurosurg Rev. 2002 Mar;25(1-2):95-8. doi: 10.1007/s101430100171.


Propofol has cerebral vascular and metabolic effects similar to those of barbiturates, and it is used to maintain neurosurgical anesthesia because it reduces cerebral metabolic rate, cerebral blood flow, and intracranial pressure. Although the use of propofol as a cerebral protectant during certain neurosurgical procedures has been advocated, consensus has not been reached as to a protective effect of propofol on cerebral ischemia. In this study we observed the neuroprotective effects of propofol during global cerebral ischemia-reperfusion injury by the use of four-vessel occlusion method in a rat model. We measured the levels of malondialdehyde as a marker of lipid peroxidation in ischemic tissue, and the results indicate that propofol plays a role in the inhibition of neuronal death induced by brain ischemia.

MeSH terms

  • Anesthetics, Intravenous / therapeutic use*
  • Animals
  • Brain Ischemia / drug therapy*
  • Brain Ischemia / metabolism
  • Lipid Peroxides / metabolism
  • Male
  • Malondialdehyde / metabolism
  • Neuroprotective Agents / therapeutic use*
  • Propofol / therapeutic use*
  • Rats
  • Rats, Sprague-Dawley
  • Reperfusion Injury / drug therapy


  • Anesthetics, Intravenous
  • Lipid Peroxides
  • Neuroprotective Agents
  • Malondialdehyde
  • Propofol