CD83 expression influences CD4+ T cell development in the thymus

Cell. 2002 Mar 22;108(6):755-67. doi: 10.1016/s0092-8674(02)00673-6.

Abstract

T lymphocyte selection and lineage commitment in the thymus requires multiple signals. Herein, CD4+ T cell generation required engagement of CD83, a surface molecule expressed by thymic epithelial and dendritic cells. CD83-deficient (CD83-/-) mice had a specific block in CD4+ single-positive thymocyte development without increased CD4+CD8+ double- or CD8+ single-positive thymocytes. This resulted in a selective 75%-90% reduction in peripheral CD4+ T cells, predominantly within the naive subset. Wild-type thymocytes and bone marrow stem cells failed to differentiate into mature CD4+ T cells when transferred into CD83-/- mice, while CD83-/- thymocytes and stem cells developed normally in wild-type mice. Thereby, CD83 expression represents an additional regulatory component for CD4+ T cell development in the thymus.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adoptive Transfer
  • Animals
  • Antibody Formation / immunology
  • Antigens, CD
  • Bone Marrow Transplantation
  • CD4 Lymphocyte Count
  • CD4-Positive T-Lymphocytes / cytology*
  • CD83 Antigen
  • Cell Lineage / immunology
  • Dermatitis, Contact / immunology
  • Gene Expression / immunology
  • Immunoglobulins / genetics*
  • Immunoglobulins / immunology*
  • Membrane Glycoproteins / genetics*
  • Membrane Glycoproteins / immunology*
  • Mice
  • Mice, Knockout
  • Stromal Cells / cytology
  • Thymus Gland / cytology*

Substances

  • Antigens, CD
  • Immunoglobulins
  • Membrane Glycoproteins