Antigenic variation and allelic exclusion

Cell. 2002 Apr 5;109(1):5-8. doi: 10.1016/s0092-8674(02)00711-0.

Abstract

Cells often express only one gene from a set of two or more. African trypanosomes appear to accomplish this monoallelic expression by segregating the selected gene into a specific nuclear body. The possibility that such a structure might explain monoallelic expression in other multigene systems is discussed here.

Publication types

  • Review

MeSH terms

  • Allelic Imbalance / genetics*
  • Animals
  • Antigenic Variation / genetics*
  • Antigenic Variation / immunology
  • Cell Compartmentation / genetics
  • Cell Nucleus Structures / genetics
  • Cell Nucleus Structures / immunology
  • Gene Expression Regulation / genetics
  • Gene Silencing / immunology
  • Transcription, Genetic / genetics
  • Trypanosoma / genetics*
  • Trypanosoma / immunology*
  • Trypanosoma / metabolism
  • Variant Surface Glycoproteins, Trypanosoma / genetics
  • Variant Surface Glycoproteins, Trypanosoma / immunology

Substances

  • Variant Surface Glycoproteins, Trypanosoma