Methicillin-resistant Staphylococcus aureus keratitis after excimer laser photorefractive keratectomy1

J Cataract Refract Surg. 2002 Apr;28(4):722-4. doi: 10.1016/s0886-3350(01)01076-8.


A 43-year-old woman in good health was admitted to the hospital 3 days after photorefractive keratectomy (PRK) in the left eye with postoperative bandage contact lens application. She had developed a severe keratitis with ulceration and hypopyon. Upon the patient's admission to the hospital, the contact lens was removed. Ofloxacin eyedrops were prescribed 4 times a day. In the hospital, the patient was successfully treated with immediate thermocautery application, followed by full-thickness keratoplasty the next day and intensive systemic and topical antibiotics. Cultures were positive for methicillin-resistant Staphylococcus aureus (MRSA). Severe MRSA keratitis is a rare cause of infection after PRK.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Drug Therapy, Combination / therapeutic use
  • Eye Infections, Bacterial / diagnosis
  • Eye Infections, Bacterial / microbiology*
  • Eye Infections, Bacterial / therapy
  • Female
  • Humans
  • Keratitis / diagnosis
  • Keratitis / microbiology*
  • Keratitis / therapy
  • Keratoplasty, Penetrating
  • Lasers, Excimer
  • Methicillin / therapeutic use*
  • Methicillin Resistance*
  • Photorefractive Keratectomy / adverse effects*
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / microbiology*
  • Staphylococcal Infections / therapy
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / isolation & purification*


  • Methicillin