Single static view 99mTc-sestamibi scintimammography predicts response to neoadjuvant chemotherapy and is related to MDR expression

Int J Oncol. 2002 May;20(5):1049-55.


We examined the relevance of a pre-treatment single static view 99mTc-sestamibi scintimammography and expression of multidrug resistance proteins as predictors of response to neoadjuvant chemotherapy for invasive breast cancer. Forty-five patients affected by primary breast cancer underwent clinical examination, mammography, sonography, 99mTc-sestamibi scintimammography, and biopsy for histopathological diagnosis before neoadjuvant chemotherapy. Expression of MDR1 and MRP mRNA were determined by RT-PCR on fine-needle aspirations. Following completion of anthracycline-based chemotherapy, clinical, mammographic, sonographic and pathological responses were determined. 99mTc-sestamibi scintimammography predicted the reduction of tumor size measured by sonography and the pathological response according to Sataloff classification (p<0.05) and tend to predict pathological response according to Chevallier (p<0.1). A negative 99mTc-sestamibi scintimammography predicted chemoresistance with a specificity of 100%. Uptake of 99mTc-sestamibi was inversely correlated to the expression of MDR1 (p<0.05) in invasive ductal carcinoma. A pre-treatment single-view 99mTc-sestamibi scintimammography is an excellent predictor of MDR1 chemoresistance and was highly specific of a lack of pathological response to chemotherapy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis
  • Adult
  • Aged
  • Antigens, CD / biosynthesis
  • Breast Neoplasms / diagnosis*
  • Breast Neoplasms / mortality
  • Chemotherapy, Adjuvant*
  • Drug Resistance, Neoplasm
  • Female
  • Humans
  • Mammography / methods*
  • Membrane Glycoproteins*
  • Middle Aged
  • Phenotype
  • Prognosis
  • RNA, Messenger / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Sensitivity and Specificity
  • Technetium Tc 99m Sestamibi / pharmacology*
  • Tetraspanin 29


  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antigens, CD
  • CD9 protein, human
  • Membrane Glycoproteins
  • RNA, Messenger
  • Tetraspanin 29
  • Technetium Tc 99m Sestamibi