Hemolytic uremic syndrome due to an altered factor H triggered by neonatal pertussis

Pediatr Nephrol. 2002 Mar;17(3):190-2. doi: 10.1007/s00467-001-0798-6.

Abstract

We report on a previously healthy newborn suffering from severe Bordetella pertussis infection who developed hemolytic uremic syndrome (HUS) a few weeks after the onset of whooping cough, with a fatal outcome. A factor H protein with abnormal mobility was found in the serum of the patient as analyzed by Western blotting, indicating that B. pertussis infection might have triggered HUS in a genetically predisposed patient.

Publication types

  • Case Reports

MeSH terms

  • Bordetella pertussis*
  • Complement Factor H / metabolism*
  • Hemolytic-Uremic Syndrome / etiology*
  • Humans
  • Infant, Newborn
  • Male
  • Whooping Cough / complications*
  • Whooping Cough / immunology

Substances

  • CFH protein, human
  • Complement Factor H