A major predisposition locus for severe obesity, at 4p15-p14

Am J Hum Genet. 2002 Jun;70(6):1459-68. doi: 10.1086/340670. Epub 2002 Apr 15.


Although the predisposition to morbid obesity is heritable, the identities of the disease-causing genes are largely unknown. Therefore, we have conducted a genomewide search with 628 markers, using multigenerational Utah pedigrees to identify genes involved in predisposition to obesity. In the genomewide search, we identified a highly significant linkage to high body-mass index in female patients, at D4S2632, with a multipoint heterogeneity LOD (HLOD) score of 6.1 and a nonparametric linkage (NPL) score of 5.3. To further delineate the linkage, we increased both the marker density around D4S2632 and the size of our pedigree data set. As a result, the linkage evidence increased to a multipoint HLOD score of 9.2 (at D4S3350) and an NPL score of 11.3. Evidence from almost half of the families in this analysis support this linkage, and therefore the gene in this region might account for a significant percentage of the genetic predisposition to severe obesity in females. However, further studies are necessary to clarify the effect that this gene has in males and in the general population.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Body Mass Index
  • Chromosome Mapping
  • Chromosomes, Human, Pair 4 / genetics*
  • Female
  • Genes, Dominant
  • Genes, Recessive
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics*
  • Genome, Human
  • Genotype
  • Humans
  • Lod Score
  • Male
  • Obesity / genetics*
  • Pedigree
  • Phenotype
  • Sex Characteristics
  • Utah


  • Genetic Markers

Associated data

  • OMIM/MIM601665