Comparative metabolism and excretion of adriamycin in man, monkey, and rat

Cancer Chemother Pharmacol. 1979;2(2):121-5. doi: 10.1007/BF00254084.

Abstract

Adriamycin and its fluorescent metabolites in bile (man, monkey, and rat) and urine (man and monkey) were determined by means of a simple, rapid, and highly reproducible high-performance liquid chromatographic procedure. Species differences in metabolism and biliary excretion were observed with respect to aldoketo reductase and conjugase activities.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Bile / metabolism
  • Biotransformation
  • Doxorubicin / metabolism*
  • Doxorubicin / urine
  • Female
  • Haplorhini
  • Humans
  • Kinetics
  • Macaca fascicularis
  • Male
  • Rats
  • Species Specificity
  • Time Factors

Substances

  • Doxorubicin