Oncocytoma-like angiomyolipoma. A clinicopathologic and immunohistochemical study of 2 cases

Arch Pathol Lab Med. 2002 May;126(5):610-2. doi: 10.5858/2002-126-0610-OLA.


We report the clinical, pathologic, and immunohistochemical features of an unusual tumor of the kidney composed of densely eosinophilic, polygonal epithelioid cells. The patients were a 56-year-old woman and a 35-year-old man. The renal tumors were discovered during follow-up for breast carcinoma and evaluation for abdominal pain, respectively. The tumors closely resembled oncocytoma in routine sections, but were negative for epithelial markers and positive for HMB-45, a pattern of reactions characteristic of angiomyolipoma. In the woman, a single additional microscopic angiomyolipoma was present in the renal parenchyma at a distance from the main tumor. Both patients are alive without recurrence 7 and 10 years after surgery, respectively. Based on clinical, morphologic, and immunophenotypic features, we conclude that these tumors are oncocytoma-like angiomyolipomas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma, Oxyphilic / chemistry
  • Adenoma, Oxyphilic / pathology*
  • Adenoma, Oxyphilic / surgery
  • Adult
  • Angiomyolipoma / chemistry
  • Angiomyolipoma / pathology*
  • Angiomyolipoma / surgery
  • Antigens, Neoplasm
  • Female
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • Kidney Neoplasms / chemistry
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / surgery
  • Male
  • Melanoma-Specific Antigens
  • Middle Aged
  • Neoplasm Proteins / analysis
  • Neoplasms, Multiple Primary / chemistry
  • Neoplasms, Multiple Primary / pathology*
  • Neoplasms, Multiple Primary / surgery
  • Neoplasms, Second Primary / chemistry
  • Neoplasms, Second Primary / pathology*
  • Neoplasms, Second Primary / surgery
  • Treatment Outcome


  • Antigens, Neoplasm
  • Melanoma-Specific Antigens
  • Neoplasm Proteins