Social disruption-induced glucocorticoid resistance: kinetics and site specificity

J Neuroimmunol. 2002 Mar;124(1-2):54-61. doi: 10.1016/s0165-5728(02)00010-3.


Social disruption (SDR) of male mice has been shown to induce a state of functional glucocorticoid (GC) resistance in splenocytes. The present study demonstrated that GC resistance developed following repeated, but not acute exposure to SDR. GC resistance was long-lasting and persisted for at least 10 days after stress. In contrast, SDR did not alter cytokine secretion from peritoneal mononuclear cells treated with corticosterone. These findings suggest that SDR-induced GC resistance may be restricted to specific sites such as the spleen.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cells, Cultured
  • Corticosterone / pharmacokinetics
  • Corticosterone / pharmacology*
  • Drug Resistance
  • Interpersonal Relations*
  • Kinetics
  • Macrophages / drug effects
  • Macrophages / physiology
  • Macrophages, Peritoneal / drug effects
  • Macrophages, Peritoneal / physiology
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Spleen / cytology
  • Spleen / drug effects*
  • Spleen / physiopathology*
  • Stress, Psychological / etiology*
  • Stress, Psychological / physiopathology*


  • Corticosterone