Galanin-like peptide stimulates food intake in the rat

Neurosci Lett. 2002 Mar 29;322(1):67-9. doi: 10.1016/s0304-3940(01)02515-0.

Abstract

We have isolated a novel hypothalamic peptide, Galanin-like peptide (GALP), as a ligand for galanin receptor subtype GalR2. To investigate the physiological role of GALP, we examined the effect of the intracerebroventricular administration of GALP and found that GALP induced food intakes. GALP had ten-fold the orexigenic activity of galanin. We also observed the anxiogenic-like behavior after the administration of 1 nmol GALP. These results suggest that GALP is a novel orexigenic and anxiogenic peptide.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anxiety / chemically induced
  • Anxiety / metabolism
  • Anxiety / physiopathology
  • Appetite Regulation / drug effects
  • Appetite Regulation / physiology*
  • Behavior, Animal / drug effects
  • Behavior, Animal / physiology
  • Dose-Response Relationship, Drug
  • Feeding Behavior / drug effects
  • Feeding Behavior / physiology
  • Galanin / metabolism*
  • Galanin / pharmacology
  • Galanin-Like Peptide
  • Hypothalamus / cytology
  • Hypothalamus / drug effects
  • Hypothalamus / metabolism*
  • Injections, Intraventricular
  • Male
  • Nerve Tissue Proteins / metabolism*
  • Nerve Tissue Proteins / pharmacology
  • Neurons / cytology
  • Neurons / drug effects
  • Neurons / metabolism*
  • Rats
  • Rats, Wistar

Substances

  • Galanin-Like Peptide
  • Nerve Tissue Proteins
  • Galanin