The tau H1 haplotype is associated with Parkinson's disease in the Norwegian population

Neurosci Lett. 2002 Apr 5;322(2):83-6. doi: 10.1016/s0304-3940(02)00106-4.


We investigated the association of Parkinson's disease (PD) with tau gene H1 haplotypes in the Norwegian population. In a sample of 96 unrelated PD cases and 68 control subjects, we observed an increased risk of PD for persons with the tau H1 haplotype (odds ratio=5.52; 95% confidence interval: 2.64-11.10; P=2.17x10(-6)). Findings provide evidence that tau participates in the PD pathogenic process and demonstrate the value of isolated populations in mapping complex traits.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Confidence Intervals
  • Female
  • Genotype
  • Haplotypes / genetics*
  • Humans
  • Male
  • Middle Aged
  • Norway / epidemiology
  • Odds Ratio
  • Parkinson Disease / epidemiology
  • Parkinson Disease / genetics*
  • tau Proteins / genetics*


  • tau Proteins

Associated data

  • OMIM/168600
  • OMIM/600116