Evaluation of Morphogenic Regulatory Activity of Farnesoic Acid and Its Derivatives Against Candida Albicans Dimorphism

Bioorg Med Chem Lett. 2002 Mar 25;12(6):895-8. doi: 10.1016/s0960-894x(02)00038-0.

Abstract

A series of farnesoic acid derivatives was prepared and their morphogenic regulatory activities were evaluated. Their inhibitory activities against yeast cell growth and yeast-to-hypha transition examined in Candida albicans cells are dependent upon the chain length as well as the substitution patterns on the isoprenoid template. The preliminary structure-activity relationship of these compounds is described to elucidate the essential structural requirements.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Candida albicans / cytology
  • Candida albicans / drug effects*
  • Cell Division / drug effects
  • Fatty Acids, Unsaturated / chemical synthesis*
  • Fatty Acids, Unsaturated / pharmacology
  • Hyphae / drug effects
  • Hyphae / growth & development
  • Inhibitory Concentration 50
  • Structure-Activity Relationship
  • Yeasts / cytology
  • Yeasts / drug effects

Substances

  • Fatty Acids, Unsaturated
  • farnesoic acid