Glucose insulin potassium infusion improves systolic function in patients with chronic ischemic cardiomyopathy

Eur J Heart Fail. 2002 Mar;4(2):181-4. doi: 10.1016/s1388-9842(01)00222-7.


Objective: We assessed the effects of glucose-insulin-potassium (GIK) by echocardiography in stable patients with ischemic dysfunction.

Methods: Twelve male patients with stable coronary disease (SCD) and ejection fraction (EF) <45% were studied for systolic function. GIK (glucose 30%, 300 insulin units and KCl 6 g/l) was infused at 1 ml/kg per h over 20 min. Hemodynamic and echocardiographic measurements were recorded at rest (T(0)), at the end (20 min) of GIK infusion (T+20), 20 and 40 min after the end of the infusion (T+40 and T+60).

Results: At T+20, a significant decrease in WMSI (wall motion score index) was observed compared with T(0) (2.16+/-0.14 vs. 2.30+/-0.16: P<0.05). An increase in EF was reported at T+40 and T+60 compared with T(0) (44.1+/-7.8% and 53.3+/-11.6% vs. 35.6+/-4.5%, respectively: P<0.01). A decrease in WMSI was observed at T+40 and T+60 compared with rest (2.02+/-0.17 and 1.93+/-0.11 vs. 2.30+/-0.16, respectively: P<0.01).

Conclusion: Our present work suggests that GIK infusion improves systolic function in patients with SCD and ejection fraction <45%. Further studies are needed to determine if short-term GIK infusion could be useful for therapeutic or diagnostic strategies in these patients.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Blood Pressure / drug effects*
  • Cardiomyopathies / complications
  • Cardiomyopathies / drug therapy*
  • Chronic Disease
  • Echocardiography
  • Follow-Up Studies
  • Glucose / administration & dosage*
  • Heart Rate / drug effects
  • Humans
  • Infusion Pumps*
  • Insulin / administration & dosage*
  • Male
  • Middle Aged
  • Potassium / administration & dosage*
  • Stroke Volume / drug effects
  • Treatment Outcome
  • Ventricular Dysfunction, Left / complications
  • Ventricular Dysfunction, Left / drug therapy


  • Insulin
  • glucose-insulin-potassium cardioplegic solution
  • Glucose
  • Potassium