Abstract
Regulatory CD4 T cells with the capacity to inhibit potentially harmful immune responses have been described in various experimental systems. Although the observations are converging towards the naturally activated CD25(+) CD4 T cells as a major population responsible for this protection, there is still considerable disagreement on the molecular and cellular requirements involved to achieve a stable immune homeostasis in vivo.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / immunology*
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Cell Differentiation
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Gastrointestinal Diseases / immunology*
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Gastrointestinal Diseases / physiopathology
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Homeostasis*
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Humans
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Inflammatory Bowel Diseases / immunology
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Inflammatory Bowel Diseases / physiopathology
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Substrate Specificity
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Thymus Gland / cytology
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Thymus Gland / immunology