Losartan-induced hepatic injury

J Clin Gastroenterol. May-Jun 2002;34(5):585-6. doi: 10.1097/00004836-200205000-00022.


Losartan, an angiotensin II receptor antagonist, is widely used for the treatment of hypertension. Clinical experience with this drug has demonstrated that it is safe. Losartan-induced hepatic toxicity is extremely rare. We report a case of severe hepatic toxicity and fibrosis caused by losartan use, and we review four previously reported cases. Drug-induced hepatic injury may be seen during the treatment of hypertension by losartan and the clinician should be aware of this toxicity, especially during the initial phase of treatment.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antihypertensive Agents / adverse effects*
  • Antihypertensive Agents / therapeutic use
  • Biopsy
  • Chemical and Drug Induced Liver Injury / etiology*
  • Female
  • Humans
  • Liver / pathology
  • Liver Cirrhosis / chemically induced*
  • Losartan / adverse effects*
  • Losartan / therapeutic use
  • Middle Aged


  • Antihypertensive Agents
  • Losartan