Association between IL-4 genotype and IL-4 production in the Japanese population

H Nakashima; K Miyake; Y Inoue; S Shimizu; M Akahoshi; Y Tanaka; T Otsuka; M Harada

doi:10.1038/sj.gene.6363830

Association between IL-4 genotype and IL-4 production in the Japanese population

Genes Immun. 2002 Apr;3(2):107-9. doi: 10.1038/sj.gene.6363830.

Authors

H Nakashima¹, K Miyake, Y Inoue, S Shimizu, M Akahoshi, Y Tanaka, T Otsuka, M Harada

Affiliation

¹ Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. hnakashi@intmed1.med.kyushu-u.ac.jp

PMID: 11960309
DOI: 10.1038/sj.gene.6363830

Abstract

We have identified that there are only two IL-4 gene haplotypes (I and II) in the Japanese population. There are significant differences among three genotypes (I/I, I/II and II/II) in the IL-4 producing proportion of peripheral Th cells using intracellular cytokine detection assay. These results make it likely that IL-4 genotype could influence the type of immune response.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Gene Frequency
Genotype
Humans
Interleukin-4 / biosynthesis*
Interleukin-4 / genetics*
Japan
Polymorphism, Genetic*
T-Lymphocytes, Helper-Inducer / immunology

Substances

Interleukin-4