Abstract
Screening of plants from South America for antitubercular activity and subsequent assay-guided fractionation resulted in the isolation and characterization of several pentacyclic triterpenoids. The MIC values of 22 triterpenoids were determined using the radiorespiratory BACTEC assay and range from 8 microM to above 128 microM. The structure-activity relationships are discussed.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antitubercular Agents / chemistry
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Antitubercular Agents / isolation & purification*
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Antitubercular Agents / pharmacology*
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Argentina
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Chile
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Dose-Response Relationship, Drug
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In Vitro Techniques
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Medicine, Traditional
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Microbial Sensitivity Tests
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Mycobacterium tuberculosis / drug effects
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Plants, Medicinal / chemistry*
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Structure-Activity Relationship
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Triterpenes / chemistry
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology*
Substances
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Antitubercular Agents
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Triterpenes