Antitubercular activity of pentacyclic triterpenoids from plants of Argentina and Chile

Phytomedicine. 1999 Nov;6(5):341-5. doi: 10.1016/S0944-7113(99)80056-7.

Abstract

Screening of plants from South America for antitubercular activity and subsequent assay-guided fractionation resulted in the isolation and characterization of several pentacyclic triterpenoids. The MIC values of 22 triterpenoids were determined using the radiorespiratory BACTEC assay and range from 8 microM to above 128 microM. The structure-activity relationships are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antitubercular Agents / chemistry
  • Antitubercular Agents / isolation & purification*
  • Antitubercular Agents / pharmacology*
  • Argentina
  • Chile
  • Dose-Response Relationship, Drug
  • In Vitro Techniques
  • Medicine, Traditional
  • Microbial Sensitivity Tests
  • Mycobacterium tuberculosis / drug effects
  • Plants, Medicinal / chemistry*
  • Structure-Activity Relationship
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology*

Substances

  • Antitubercular Agents
  • Triterpenes