Cytotoxic dammarane glycosides from processed ginseng

Chem Pharm Bull (Tokyo). 2002 Apr;50(4):538-40. doi: 10.1248/cpb.50.538.

Abstract

Steaming ginseng at high temperature increased its cytotoxicity to SK-Hep-1 hepatoma cancer cells. HPLC separation and fractionation followed by MTT assay revealed that ginsenosides Rg3, Rg5, Rk1, Rs5, and Rs4 are the active principles. Their 50% growth inhibition concentration (GI50) values were 41, 11, 13, 37, and 13 microM, respectively. Cisplatin had a GI50 of 84 microM in the same assay conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Carcinoma, Hepatocellular / pathology
  • Cell Survival / drug effects
  • Chromatography, High Pressure Liquid
  • Cisplatin / pharmacology
  • Dammaranes
  • Ginsenosides / chemistry
  • Ginsenosides / isolation & purification
  • Ginsenosides / pharmacology
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Liver Neoplasms / pathology
  • Panax / chemistry*
  • Plant Extracts / chemistry
  • Plant Roots / chemistry
  • Temperature
  • Triterpenes / chemistry
  • Triterpenes / isolation & purification*
  • Triterpenes / pharmacology
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents, Phytogenic
  • Ginsenosides
  • Glycosides
  • Plant Extracts
  • Triterpenes
  • Cisplatin