Phagocytosis and killing of intracellular pathogens: interaction between cytokines and antibiotics

Curr Opin Infect Dis. 2000 Jun;13(3):233-240. doi: 10.1097/00001432-200006000-00006.


Phagocytosis and bacterial killing are the primary functions of macrophages. Among the mechanisms involved in the phagocytic process, cytokines, especially those of T-helper 1 profile, appear to influence considerably the internalization and the intracellular fate of the pathogen within the macrophage. In particular, the evidence for a cooperation of cytokines with antibiotics in intracellular infection could provide new therapeutic approaches to intracellular infectious diseases in the future.