Small Ligands Interacting With the Phosphotyrosine Binding Pocket of the Src SH2 Protein

Bioorg Med Chem Lett. 2002 May 6;12(9):1295-8. doi: 10.1016/s0960-894x(02)00140-3.

Abstract

Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.

MeSH terms

  • Binding Sites
  • Ligands
  • Phosphotyrosine / metabolism*
  • src Homology Domains*

Substances

  • Ligands
  • Phosphotyrosine