Dynamic multiphosphorylation passwords for activity-dependent gene expression

Neuron. 2002 Apr 11;34(2):179-82. doi: 10.1016/s0896-6273(02)00664-5.


Synapse-to-nucleus signaling leading to CREB-mediated transcription is important for neuronal plasticity. Nuclear CREB phosphorylation at Ser133 allows convergence of multiple kinase pathways driven by neuronal activity and links them to transcriptional activation. But, can various pathways share a common effector mechanism (phosphorylating Ser133) while generating distinct patterns of gene expression? We review three Neuron articles that highlight novel ways Ca(2+) signals can trigger multiple phosphorylation events working in combination to control CREB and its interaction with coactivator molecules.

Publication types

  • Comment
  • Editorial
  • Review

MeSH terms

  • Animals
  • Brain / physiology
  • Calcium Signaling / physiology*
  • Cyclic AMP Response Element-Binding Protein / physiology*
  • Gene Expression Regulation / physiology*
  • Neuronal Plasticity / physiology
  • Phosphorylation


  • Cyclic AMP Response Element-Binding Protein