Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients

Neurology. 2002 Apr 23;58(8):1277-9. doi: 10.1212/wnl.58.8.1277.


Levels of the potent pro-inflammatory prostaglandin E(2) (PGE(2)) are elevated in postmortem spinal cords from patients with ALS, and inhibition of a key PGE(2)-synthesizing enzyme, cylcooxygenase-2, is neuroprotective in an in vitro model of ALS. The authors report that 82% of the patients with ALS studied had 2 to 10 times higher PGE(2) levels in CSF compared with normal control subjects. That affected areas of the CNS are inflamed in ALS supports this. CSF PGE(2) measurement may be useful in monitoring treatment for ALS.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Amyotrophic Lateral Sclerosis / cerebrospinal fluid*
  • Biomarkers
  • Dinoprostone / cerebrospinal fluid*
  • Female
  • Humans
  • Immunoassay
  • Luminescent Measurements
  • Male
  • Middle Aged


  • Biomarkers
  • Dinoprostone