Paraoxonase1-192 polymorphism modulates the effects of regular and acute exercise on paraoxonase1 activity

J Lipid Res. 2002 May;43(5):713-20.


Regular exercise practise is a protective factor against coronary heart disease and enhances antioxidant systems, whereas acute exercise appears to be a major source of increased oxidative stress. Paraoxonase1 (PON1) is an antioxidant HDL-linked enzyme, whose activity toward paraoxon (PON1 activity) is strongly modulated by the PON1-192 polymorphism, comprising Q and R alleles for low and high PON1 activity, respectively. Another polymorphism at the PON1 locus, the PON1-55, modulates PON1 protein and activity levels. PON1 activity, lipid levels, and oxidized LDL concentration were determined in 17 healthy young volunteers before and after a 16-weeks aerobic exercise training period. Furthermore, PON1 activity was analyzed after a bout of exercise in both situations. We found that regular exercise was associated with a decrease in oxidized LDL levels, and an increase in PON1 activity in QQ subjects and with a decrease in PON1 activity in R carriers. A bout of exercise produced an increase in PON1 activity just after the bout of exercise, followed by a decrease in its activity. A recovery of the basal PON1 activity levels at 24 h was found in QQ subjects regardless of their training status and in trained R carriers, but not in untrained R carriers. These results suggest that the effects of regular and acute exercise on PON1 activity levels are modulated by PON1-192 polymorphism. Changes were less evident for the PON1-55 polymorphism.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aryldialkylphosphatase
  • Body Height
  • Body Mass Index
  • Body Weight
  • Chi-Square Distribution
  • Cholesterol / blood
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Coronary Disease / prevention & control
  • Esterases / genetics*
  • Esterases / metabolism*
  • Exercise / physiology*
  • Female
  • Genetic Carrier Screening
  • Genotype
  • Humans
  • Isoenzymes / genetics
  • Isoenzymes / metabolism
  • Lipoproteins, LDL / blood
  • Male
  • Physical Endurance / physiology
  • Physical Fitness*
  • Reference Values
  • Smoking
  • Time Factors
  • Triglycerides / blood


  • Cholesterol, HDL
  • Cholesterol, LDL
  • Isoenzymes
  • Lipoproteins, LDL
  • Triglycerides
  • oxidized low density lipoprotein
  • Cholesterol
  • Esterases
  • Aryldialkylphosphatase
  • PON1 protein, human