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Review
, 3 (3), 176-88

The Art and Design of Genetic Screens: Drosophila Melanogaster

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Review

The Art and Design of Genetic Screens: Drosophila Melanogaster

Daniel St Johnston. Nat Rev Genet.

Abstract

The success of Drosophila melanogaster as a model organism is largely due to the power of forward genetic screens to identify the genes that are involved in a biological process. Traditional screens, such as the Nobel-prize-winning screen for embryonic-patterning mutants, can only identify the earliest phenotype of a mutation. This review describes the ingenious approaches that have been devised to circumvent this problem: modifier screens, for example, have been invaluable for elucidating signal-transduction pathways, whereas clonal screens now make it possible to screen for almost any phenotype in any cell at any stage of development.

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