Significance of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) for detection of renal cell carcinoma and immunohistochemical glucose transporter 1 (GLUT-1) expression in the cancer

Int J Urol. 2002 Jan;9(1):15-8. doi: 10.1046/j.1442-2042.2002.00416.x.


Objective: Positron emission tomography (PET) is now primarily used in oncological indication owing to the successful application of fluorine-18 fluorodeoxyglucose (FDG) in an increasing number of clinical indications. Glucose transporter 1 (GLUT-1) is recognized as a major early marker of cellular malignant transformation. The aims of this study were to assess whether FDG-PET is a useful diagnostic tool for renal cell carcinoma and to compare the pathologic characteristics.

Methods: Nineteen consecutive patients who had renal cell carcinoma were examined using FDG-PET preoperatively. The results of PET were then compared to the histology obtained after radical surgery and the immunoreactivity of GLUT-1 was also studied.

Results: Pathologic examination confirmed that all 19 patients suffered from renal cell carcinoma. Increased FDG uptake was found in six of the 19 patients (31.5%). The immunohistochemical examination of GLUT-1 in renal cell carcinoma produced different results in each patient. There was no correlation with GLUT-1 immunoreactivity and FDG-PET positivity.

Conclusion: These results suggest that FDG-PET may not be a useful diagnostic tool for renal cell carcinoma.

MeSH terms

  • Aged
  • Carcinoma, Renal Cell / chemistry
  • Carcinoma, Renal Cell / diagnostic imaging*
  • Carcinoma, Renal Cell / metabolism*
  • Female
  • Humans
  • Immunohistochemistry
  • Kidney Neoplasms / chemistry
  • Kidney Neoplasms / diagnostic imaging*
  • Kidney Neoplasms / metabolism*
  • Male
  • Middle Aged
  • Monosaccharide Transport Proteins / analysis
  • Monosaccharide Transport Proteins / biosynthesis*
  • Tomography, Emission-Computed*


  • Monosaccharide Transport Proteins