The effect of Gd-DTPA on T(1)-weighted choline signal in human brain tumours

Magn Reson Imaging. 2002 Jan;20(1):127-30. doi: 10.1016/s0730-725x(02)00485-x.


The influence of Gd-DTPA on T(1)-weighted (T(1)W) proton MR spectra has been investigated in 19 patients with histologically verified low (n = 13) or high-grade (n = 6) gliomas. Repeat measurements were performed on 9 patients (7 low-grade and 2 high-grade), with 28 examinations performed in total. Comparison of spectra obtained before and after 0.2 mmol/kg Gd-DTPA showed contrast agent induced broadening of the choline signal without significant signal area change. Lack of enhancement of the choline signal with the T(1)-weighted acquisitions implies that the contrast agent and the trimethylamine-containing species do not undergo significant direct interaction. Contrast agent induced changes in the choline signal observed in this and previous studies may, therefore, be attributable to T2*/susceptibility-based effects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain Neoplasms / diagnosis*
  • Choline / analysis
  • Contrast Media / pharmacology*
  • Gadolinium DTPA / pharmacology*
  • Glioma / diagnosis*
  • Humans
  • Magnetic Resonance Spectroscopy
  • Water


  • Contrast Media
  • Water
  • Gadolinium DTPA
  • Choline